World Journal of Case Reports

Editor Name: Georgios I. Laliotis

Country: Greece

University: University Of Crete

Designation: M.D

Department: Laboratory of Cancer Biology

Email: glaliot7@gmail.com; georgios.laliotis@osumc.edu

BIOGRAPHY:

Education:

1. University Of Crete, School Of Medicine ” 2011-2017, Medical Degree, (M.D.) GPA 8.59 summa cum ladae.

2. University Of Crete, School Of Medicine -2018-Present. Doctor of Philosophy, (Ph.D.), ˜The epigenetic regulation of U2AF2 pre-mRNA alternative splicing by AKT3-phosphorylated IWS1, controls the genomic stability and the therapeutic response of PD-L1 blockade in patients with Lung Adenocarcinoma™. Expected Graduation September 2021.

3. The Ohio State University, College of Public Health- 2019-Expected Graduation May 2021, Master of Public Health (M.P.H)-The Master of Public Health - Program for Experienced Professionals (MPH-PEP), Clinical Translational Medicine

HONORS AND AWARD

2011: State Scholarship Foundation - Scholarship for the top 10 students entering University Of Crete, Medical School

2013: State Scholarship Foundation - Scholarship for 2nd best student in University Of Crete, School Of Medicine in 2nd medical year

2015: State Scholarship Foundation - Scholarship for 2nd best student in University Of Crete, School Of Medicine in 4th medical year

2016: 2nd place -International Quiz Of Medical Knowledge -10th Hellenic Congress Of Medical Students, Patra, May 2016

2017: Stavros Nirachos Foundation Scholarship for Scientific Excellence- Scholarship for graduating 2nd from University of Crete, School of Medicine.

2018: The Pelotonia Post-Doctoral Scholarship for cancer Research- The Ohio State University Comprehensive Cancer Center, Columbus, OH

RESEARCH EXPERIENCE

1. Laboratory of Cancer Biology, University Of Crete, 2011-2014 Pharmacogenomic project (gene expression profiles, SNPs analysis, and mutations analysis)-Establishment of markers for evaluation of micrometastatic disease in patients with colorectal cancer-Mentor : Ass. Prof. Ioannis Sougklakos

2. Laboratory of Infectious Diseases, University Of Crete, 2015-201 fungal infections and antimicrobial agents in immunosuppressant patients - Mentor: Prof.George Samonis.

3. Official Member of Clinical Trial Unit in Oncology Department “ University Hospital Of Heraklion, 2015-2017.Â Participating in organising and analysing the protocols and results of double-blinded stage 2 and 3 clinical trials for anti-neoplasmatic therapies in oncologic patients - Mentors: Ass. Prof. Ioannis Sougklakos - Prof. George Samonis.

4. Member of HALT-3 trial team assigned by Hellenic Centre of Disease Control: June 2016-December 2017. Protocol for point prevalence surveys of healthcare-associated infections and antimicrobial use in long-term care facilities in Crete - Mentor: Prof. Of Infectious Diseases Achilleas Gkikas.

5. Post-Doctoral Research Fellow, Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA. December 2017-April 2018.

6. Post-Doctoral Research Fellow, The Ohio State Comprehensive Cancer Center- James and Solove Research Institute, Columbus, OH. May 2018-Present.

PROFESSIONAL EXPERIENCE

Clinical Elective- Boston Medical Center, Department of Nephrology, March 2018-April 2018.

Supervisors : Rivka Avalon, M.D. Associate Professor, Boston University School Of Medicine, Laurence H. Beck, M.D., Ph.D., Associate Professor, Boston University School Of Medicine, Boston, MA.

September 2015-January 2016 - University Hospital Of Heraklion : Clinical Clerkship in Surgery - rotated in : orthopedics, intensive care unit, urology , surgical oncology, general surgery.

February 2016-June 2016 - University Hospital Of Heraklion : Clinical Clerkship in Internal Medicine - rotated in : infectious diseases , geriatrics, nephrology, cardiology, pneumonology, gastroenterology.

September 2016-January 2017 - University Hospital Of Heraklion : Clinical Clerkship in Obstetrics, Emergency Unit, pediatrics

February 2017-June 2017 - University Hospital of Heraklion : Clinical Clerkship in Opthalmology, INT, Neurology, Psychiatry, Primary Care.

PUBLICATIONS

1. Kountourakis, P., Souglakos, J., Gouvas, N., Androulakis, N., Laliotis G., Athanasiadis, A., Boukovinas, I., ... & Georgiou, P. (2016). Adjuvant chemotherapy for colon cancer: a consensus statement of the Hellenic and Cypriot Colorectal Cancer Study Group by the HeSMO. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology, 29(1), 18.

2. Laliotis G., Paraskevopoulou M, Taraslia V., Vlahos I, Palmieri D., Coppola V., Carbonne D and Philip N. Tsichlis., The epigenetic regulation of U2AF2 pre-mRNA alternative splicing by AKT3-phosphorylated IWS1, controls the genomic stability and the therapeutic response ofÂ DL1 blockade in patients with Lung Adenocarcinoma™, manuscript under review in Cancer Cell™.Â

3. Laliotis G., Paraskevopoulou M, Palmieri D., Chavdoula E., Coppola V., and Philip N. Tsichlis. IWS1 regulates ROS formation and response to cisplatin treatment by regulating the xCT/SLC7A11 cysteine transporter transcription in lung adenocarcinoma™, manuscript submitted and under review in Molecular Cell™.

4. Laliotis G., Peter Vogt and Philip N. Tsichlis, Phosphoinositide 3-kinase, a Field in Transition™, invited Review article submitted in Special Issue of MDPI Biomolecules™.

5. Anastas V., Laliotis G., Chavdoula E. And Philip N. Tsichlis The crosstalk of H3K36me3 and H3K27me3 in human cancer and disease™, Invited Review Article submitted in Cells™

PRESENTAÎ¤IONS/POSTERS

1. Laliotis G., Paraskevopoulou M, Taraslia V., Vlahos I, Palmieri D., Coppola V., Orlacchio A.Â and Philip N. Tsichlis. IWS1/AKT3 axis controls the alternative splicing of U2AF2 and regulates the DNA Damage response through regulation of p21/PUMA splicing.™, American Association of Cancer Research 2019 Annual Meeting, March 29-April 2019, Atlanta, GA.

2. Laliotis G., Paraskevopoulou M, Taraslia V., Vlahos I, Palmieri D., Coppola V., and Philip N. Tsichlis, p-IWS1/AKT3 axis control U2AF2 alternative pre-mRNA splicing by increased H3K36me3 distribution and recruitment of LEGDF-SRSF1 spliceosomal complex™, 84th Cold Spring Harbor Laboratory Symposium, RNA Control and regulation™, May 29-June 3, One Bungtown Road, Cold Spring Harbor, NY.

3. Review of Hereditary Breast cancer syndromes™, 4th Alumni Meeting of Cretan Association of Surgical Oncology, Heraklion, April, 2017.

4. Review of available and future treatments in metastatic melanoma', 3rd Alumni Meeting of Cretan Association of Surgical Oncology, Heraklion, May, 2016

5. Umbilical cord hematopoietic stem cells : properties and clinical applications' , 10th Hellenic Congress Of Medical Students, Patra, May 2016.

6. Potential Applications Of Circulated Tumor Cells in clinical drug development for metastatic colorectal cancer', 2nd International Symposium on Advances in Circulating Tumor Cells (ACTC), October 8th “11th, 2014, Crete, Greece.