World Journal of Case Reports

Editor Name: Zhuoya Wan

Designation: Research Fellow

Country: USA, Pennsylvania

University: University of Pittsburgh School of Pharmacy

Research Interest: Drug Delivery, Immunology, Computational Biology Cancer Immunotherapy, Leukemia

BIOGRAPHY:

Zhuoya Wan is a researcher of Pharmaceutical Science in Pharmaceutics and Immunology at the University of Pittsburgh, School of Pharmacy. Wan is the recipient of the graduate student excellence award at University of Pittsburgh and selective oral presentation award at the ACS National Meeting, America Society of Chemistry. In addition, Wan is also a peer reviewer in BMC cancer, Cancer Biology& Therapy, and Bioscience Reports.

EDUCATION BACKGROUND

University of Pittsburgh (PITT) 08/2017-Present PhD student, Pharmaceutical Science, Advisor: Song LiCenter for Pharmacogenetics, School of Pharmacy, University of Pittsburgh

University of Pittsburgh (PITT) 08/2016-08/2017

M.S., Pharmaceutics, Advisor: Song Li Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh

SiChuan University (SCU) 09/2011-09/2015

B.S., Pharmacy, Advisor: Zhirong Zhang and Yuan Huang

Sichuan University,West China School of Pharmacy

Positions and Employments

Research Fellow, Center for Pharmacogenetics, Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, USA 2016-Present

Research Assistant, Key Lab of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

SELECTED AWARDS & HONORS

1. Graduate Student Excellence Award ($2000), University of Pittsburgh, 2020

2. Selective Oral Presentation Award ($225), ACS National Meeting, America Society of Chemistry, 2019

3. Featured Media Interview: An interview with Zhuoya Wan in Cancer Immunotherapy, RxNet London, 2019

4. PITT-GPSG Travel Grant, University of Pittsburgh, 2019

5. Graduate Program Council (GPC) Travel Award, PITT School of Pharmacy, 2019

6. Editor of AAPS Pitt Student Chapter Newspaper 2018-2020 (Chief Editor in 2020)

7. Research Fellowship, University of Pittsburgh (2016-present)

8. Teaching Fellowship, University of Pittsburgh (2016-present)

9. National Scholarship (2012), Ministry of Education of China

10. First Class Scholarship (2012, 2014); Second Class Scholarship (2013), Sichuan University

11. National Undergraduate Research Achievement (2014), First Prize, China Association Higher Education

12. National Excellent Research Project Leader (2014), Innovation Program

13. Best Oral Presentation award of Medical Group, Top-3 Outstanding Oral Presentation Award, Annual Conference of Undergraduate Innovation and Entrepreneurship (2014), Sichuan University

14. Research essay was finally rewarded First Prize, Innovation Program (2014), Sichuan University

15. Excellent Graduation Project (2015), Sichuan University

16. Excellent Student Leader for Science Department (2014), Sichuan University

17. Excellent Student Leader of Academic Association (2013), Sichuan University

18. Founder and President of Drug Delivery System (DDS) Research Association in Sichuan University

PROFESSIONAL ACTIVITIES

Academic Members and Employments

Chair, American Association of Pharmaceutical Scientist (AAPS), PITT Student Chapter (2017-2020)

Committee Member, Graduate and Professional Student Organization, PITT (2017-2019)

Committee Member, sub-group leader in restart-research group (COVID-9 Hazard Assessment), 2020

American Association for the Advancement of Science (AAAS)

American Association of Pharmaceutical Scientist (AAPS)

Controlled Release Society (CRS)

American Chemical Society (ACS)

The American Institute of Chemical Engineers (AIChE)

PUBLICATIONS

GoogleScholar:

https://scholar.google.com/citations?user=0ssHBk0AAAAJ&hl=en&oi=ao

1. Zhuoya Wan, Jingjing Sun, Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy; Acta Biomaterialia., 90, 300-313, 2019 IF=7.2

2. Jingjing Sun*, Zhuoya Wan*, Jieni Xu* (Co-first author), Song Li, Tumor Size-Dependent Abscopal Effect of Polydopamine-coated NPs Co-loaded with Gemcitabine and IDO Inhibitor for Immunochemo-photothermal Therapy, Biomaterials, 2020 IF=10.2

3. Zhuoya Wan, Xu Song, Qiang Ao, Recent Advancement of Nanomedicine, Immunotherapy and Combination Therapy for Leukemia, Journal of Leukocyte Biology, 2020 (In Press) IF=4.3

4. Zhuoya Wan, Pearl Moharil, Ruohui Zheng, Polymeric Micelles in Cancer Immunotherapy, Molecules, 2021(In Press) IF=3.267

5. Zhuoya Wan, Zhang Fan, Yang Rui, Ma Shanfu, Huang Yuan, The impact of different molecular weights of trimethyl chitosan on insulin-loaded chitosan nanoparticles, West China Journal of Pharmaceutical Sciences., 2016; Zhuoya., Wan et al., collected by National 7th Chinese Pharmaceutical Students’ Creativity Forum (conference paper)., 31 (3), 227-229, 2016

6. Jingjing Sun, Zhuoya Wan, Triple Drugs Co-Delivered by a Small Gemcitabine-Based Carrier for Pancreatic Cancer Immunochemotherapy; Acta Biomaterialia., 106, 289-300, 2020 IF=6.4

7. Xu Song, Zhuoya Wan, Lin Li, Xun Sun, Tao Gong, Zhirong Zhang, A multi-target peptide for potentiating chemotherapy by modulating tumor microenvironment; Biomaterials., 108, 44-56, 2017 IF=10.3

8. Juan Zhao, Zhuoya Wan, Chuchu Zhou, Qin Yang, Jianxia Dong, Xu Song, Tao Gong, Hyaluronic Acid Layer-By-Layer (LbL) Nanoparticles for Synergistic Chemo-Phototherapy, Pharmaceutical Research., 35 (10), 196, 2019 IF=3.4

9. Jingjing Sun, Yichao Chen, Jieni Xu, Xiangping Song, Zhuoya Wan, High Loading of Hydrophobic and Hydrophilic Agents via Small Immunostimulatory Carrier for Enhanced Tumor Penetration and Combinational Therapy, Theranostics., 10 (3), 1136, 2020 IF=8.7

10. Jingjing Sun, Lingyi Sun, Jianchun Li, Jieni Xu, Zhuoya Wan, A multi-functional polymeric carrier for simultaneous positron emission tomography imaging and combination therapy, Acta Biomaterialia., 75, 312-322, 2018 IF=6.4

11. Kejun Jiang, Xu Song, Liuqing Yang, Lin Li, Zhuoya Wan, Xun Sun, Tao Gong, Qing Lin, Zhirong Zhang, Enhanced antitumor and anti-metastasis efficacy against aggressive breast cancer with a fibronectin-targeting liposomal doxorubicin; Journal of Controlled Release., 271, 21-30, 2018 IF=7.9

12. Qin Yang, Tiantian Tan, Juan Zhao, Chuchu Zhou, Chenqi Guo, Zhuoya Wan, Xu Song, Tao Gong., A reversible decomposition approach for the formation of injectable, excipient‐free, self‐assembling nanocrystals, Chemical Communications., 55 (21), 3144-3147, 2019 IF=6.16

13. Zhangyi Luo, Jieni Xu, Jingjing Sun, Haozhe Huang, Ziqian Zhang, Weina Ma, Zhuoya Wan, Co-delivery of 2-Deoxyglucose and a glutamine metabolism inhibitor V9302 via a prodrug micellar formulation for synergistic targeting of metabolism in cancer; Acta Biomaterialia., 105, 239-252, 2020 IF=6.4

14. Yanhua Liu; Jingjing Sun; Yixian Huang; Yichao Chen; Jiang Li; Lei Liang; Jieni Xu; Zhuoya Wan; Bei Zhang; Zuojun Li, Song Li; Metformin-conjugated micellar system with intratumoral pH responsive de-shielding for co-delivery of doxorubicin and nucleic acid, Biochemical Pharmacology., 2021

15. Xiaoli Yi, Xianghong Lian, Jianxia Dong, Zhuoya Wan, Chunyu Xia, Xu Song, Yao Fu, Tao Gong, Zhirong Zhang, Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers; Molecular Pharmaceutics., 12 (11), 4085-4098, 2015 IF=4.4

16. Chuchu Zhou, Chenqi Guo, Wenhao Li, Juan Zhao, Qin Yang, Tiantian Tan, Zhuoya Wan, Jianxia Dong, Xu Song, Tao Gong., A novel honokiol liposome: formulation, pharmacokinetics, and antitumor studies, Drug Development and Industrial Pharmacy., 44 (12), 2005-2012, 2018 IF=2.3

17. Xu Song, Huan Liu, Qin Yang, Zhuoya Wan, Xun Sun, Tao Gong, Zhirong Zhang, A Submicron Emulsion for Intravenous Injection of 7-Ethyl-10-Hydroxycamptothecin: Characterization, Pharmacokinetic and Biodistribution Studies, In Vitro and In Vivo Antitumor Effect, Latin American Journal of Pharmacy., 35 (6), 1369-1377, 2016

Selected Oral presentations

1. Podium Award, 12th Annual Pharmaceutical Sciences Research Symposium, Targeting Metabotropic Glutamate Receptor 4 for Cancer Immunotherapy, American Association of Pharmaceutical Scientist (Pitt-Duq-WVU), March, 2021 *Ranked 1st in the Section of Pharmacology

2. Ten-minutes On-Demand Talk, Control Release Society Annual Meeting, Rational Design of An AraC-Based Ultrasmall Prodrug Nanocarrier for Effective Leukemia Combination Therapy, Virtual Meeting, July, 2020

3. Podium Award, 11th Annual Pharmaceutical Sciences Research Symposium, Triple drugs co-delivered by a small AraC-based carrier for leukemia immunochemotherapy, American Association of Pharmaceutical Scientist (Pitt-Duq-WVU), January, 2020

4. Oral Presentation, 2019 AIChE Annual Meeting, Biomaterials for Immunological Applications, Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy, Orlando, November, 2019

5. Invited Oral Presentation, 2019 Cell Therapies and Immunotherapy Conference, Society for Biological Engineering, AIChE Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy, San Francisco, October, 2019

6. Oral Presentation, ACS Fall 2019 National Meeting & Exposition, Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy, American Chemical Society, San Diego, August, 2019

7. Podium Award, 8th National Chinese Pharmaceutical Students’ Creativity Forum, The impact of different molecular weights of trimethyl chitosan on insulin-loaded chitosan nanoparticles, China Pharmaceutical University, Nanjing, November, 2015

8. Podium Award, 7th National Chinese Pharmaceutical Students’ Creativity Forum, The impact of different molecular weights of trimethyl chitosan on insulin-loaded chitosan nanoparticles, Guangdong Pharmaceutical University, Guangzhou, November, 2014

9. Podium Award, Undergraduate Innovation Forum of Sichuan University, The impact of different molecular weights of trimethyl chitosan on insulin-loaded chitosan nanoparticles, August, 2014