Giant Dedifferentiated Retroperitoneal Liposarcoma a Multidisciplinary Approach

Case Report | Open Access

Volume 2023 - 2 | Article ID 217 | http://dx.doi.org/10.51521/WJCRCI.2023.2103

Giant Dedifferentiated Retroperitoneal Liposarcoma a Multidisciplinary Approach

Academic Editor: Guangyu Li

Received 2023-02-24
Revised 2023-03-02
Accepted 2023-03-05
Published 2023-03-10

SANTIAGO NIÑO^*#, ISABELA CASTANEDA, JOSEFINA PRINCIPE, ANNA MARY JOSE, ABDUL RAFAY PASHA

^#*Santiago Niño, Colegio mayor de nuestra señora del Rosario, Colombia, Bogota, Physician, Postal code:111156, Email: Sant9812@gmail.com
Isabela Castaneda, Pontificia Universidad Javeriana, Colombia, Bogota Physician, Postal code: 111156, Email: isa.c98@hotmail.com
Josefina Principe, Pontificia Universidad Católica Argentina, Argentina, Buenos Aires, Physician, Postal code: B1713, Email: joselaprincipe@gmail.com
Anna Mary Jose, Physician, India, Postal code: 77590 , Email: annamaryjose0109@gmail.com
Abdul Rafay Pasha, Allama Iqbal medical college, Lahore, Pakistan, Student, Postal code: 88301, Email: abdulrafay285@gmail.com

Corresponding Author: ^#*Santiago Niño, Colegio mayor de nuestra señora del Rosario, Colombia, Bogota, Physician, Postal code:111156, Email: Sant9812@gmail.com

Citation: Santiago Niño^*#, Isabela Castaneda, Josefina Principe, Anna Mary Jose, Abdul Rafay Pasha, (2023) Giant Dedifferentiated Retroperitoneal Liposarcoma a Multidisciplinary Approach. World J Case Rep Clin Imag. 2023 Feb-Mar; 2(1)1-6.

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ABSTRACT

Liposarcomas are defined as malignant adipocytic differentiation tumors. They are mainly divided into three morphological subgroups, with a wide diversity of biological behaviors, ranging from well-differentiated tumors with low metastatic potential to pleomorphic subtypes that tend to be high-grade and with a high rate of distant metastasis, like dedifferentiated subtype. The prognosis of retroperitoneal liposarcomas is poor compared to other retroperitoneal sarcomas, with complete surgical resection being the gold standard in management and the most important prognostic factor. However, in well-differentiated histological subtypes where the margins are not well defined, it may require resection of contiguous organs and combined management with radiotherapy and chemotherapy as an adjuvant or neoadjuvant treatment to prevent future recurrences. In this report, we present the surgical excision of a retroperitoneal liposarcoma without the involvement of contiguous structures and its possible genetic or syndromic relationship in a patient with a history of thymoma and pulmonary hamartoma.